Name |
Expression |
MW |
Function |
Other Names |
Family |
CD301 |
immature DC |
38kD |
binds Tn
antigen, uptake of glycosylated antigens |
MGL, HML |
C type
lectin SF, ASV |
CD302 |
some
myeloid and Hodgkin’s cell lines |
19-28kD |
a fusion
protein in Hodgkin’s lymphoma w/ DEC-205 |
DCL1, BIMLEC |
Type I TM
C-type lectin receptor |
CD303 |
plasmacytoid dendritic cells |
38kD |
inhibit
IFN-α production |
BDCA2, HECL |
C-type
lectin SF ASV |
CD304 |
neurons,
CD4+/CD25+ Treg, DC, endothelial and tumor cells |
130kD |
interacts w/
VEGF165 & semaphorins, co-receptor with plexin, axonal guidance,
angiogenesis, cell survival, migration |
BDCA4,
neuropilin 1 |
semaphorin
family |
CD305 |
NK, B, T,
mono |
32-40kD |
inhibitory
receptor on NK and T cells |
LAIR1 |
IgSF, ASV |
CD306 |
unknown |
|
soluble,
mucosal tolerance |
LAIR2 |
IgSF, ASV |
CD307 |
B subset, B
lymphoma |
55-105kD |
B cell
development, translocation in some lymphomas |
IRTA2 |
IgSF (Fc
receptor), ASV |
CD309 |
endothelial, angiogenic precursor cells, hemangioblast |
230kD |
binds VEGF,
regulates adhesion and cell signaling |
VEGFR2, KDR |
Type III TM
tyr kinase |
CD312 |
mono, mac,
moDC, granslow |
90kD |
cell
adhesion and migration for phagocytosis |
EMR2 |
EGFR-7TM ASV |
CD314 |
NK, CD8+
activated, NK1.1+ T, some myeloid cells |
42kD |
binds MHC
class I, MICA, MICB, Rae1 & ULBP4, activates cytolysis and cytokine
production, costimulation |
NKG2D, KLR |
Type II
lectin-like receptor |
CD315 |
B subset,
monoact |
135kD |
w/ CD81 and
CD9 |
CD9P1,
SMAP6, FPRP, PTGFRN |
IgSF |
CD316 |
B, T cells,
low on NK cells |
63-75kD |
w/ CD81 &
CD9; involved in cell migration |
EWI2, PGRL,
CD81P3, KASP |
IgSF8 |
CD317 |
B, T, NK,
mono, DC, fibroblast cell line, myeloma |
30-36kD |
pre-B cell
growth, overexpressed in multiple myeloma |
BST2, HM1.24 |
Type II |
CD318 |
HSC (subset
of CD34+), tumors |
135kD |
cell
adhesion with ECM |
CDCP1,
SIMA135 |
Type I, ASV |
CD319 |
T, B and DC
subset, NK, upregulated in DC |
66kD |
regulate T
and NK cells |
CRACC,
SLAMF7 |
Ig TM |
CD320 |
follicular
DC, germinal centers |
30kD |
B
proliferation, tumor formation |
8D6A, 8D6 |
LDL receptor |
CD321 |
platelet
receptor, epithelia and endothelial, platelets |
35kD |
tight
junctions |
JAM1, F11
receptor |
IgSF, Type
I, ASV |
CD322 |
HEV, other
endoth |
43kD |
cell
adhesion, lymphocyte homing to secondary lymphoid organs |
JAM2, VE-JAM |
IgSF |
CD324 |
non-neural
epith |
120kD |
cell
adhesion, homotypic interaction & binds αE/β7 |
E-Cadherin,
Uvomorulin |
cadherin SF |
CDw325 |
brain,
skeletal and cardiac muscle |
140kD |
cell
adhesion, neuronal recognition |
N-Cadherin,
NCAD |
cadherin SF |
CD326 |
most epith
cell membranes |
35-40kD |
growth
factor receptor? |
Ep-CAM, Ly74 |
|
CDw327 |
placenta,
spleen, B . sialic-acid dependent |
|
adhesion,
membrane- bound & secreted forms |
SIGLEC6 |
IgSF |
CDw328 |
resting and
activated NK, placenta, liver, spleen, lower in gran & mono |
75kD |
sialic-acid
dependent adhesion, inhibit NK activation, hemopoiesis |
SIGLEC7,
AIRM-1 |
IgSF |
CDw329 |
neutrophils
and mono |
|
sialic-acid
dependent adhesion molecule |
SIGLEC9 |
IgSF |
CD331 |
fibroblasts, epithelial |
30kD |
binds FGF,
high affinity receptor for fibroblast growth factors |
FGFR1,
Fms-like tyrosine kinase-2, KAL2, N-SAM |
TM tyr
kinase |
CD332 |
fibroblasts, epithelial |
115-135kD |
binds FGF,
high affinity receptor for fibroblast growth factors |
FGFR2, BEK,
KGFR |
TM RTK
family |
CD333 |
fibroblasts, epithelial |
115kD |
binds FGF,
high affinity receptor for fibroblast growth factors |
FGFR3, ACH,
CEK2 |
TM RTK
family |
CD334 |
fibroblasts, epithelial |
110kD |
binds FGF,
high affinity receptor for fibroblast growth factors |
FGFR4, JTK2,
TKF |
TM RTK
family |
CD335 |
NK |
46kD |
activates NK
cells upon non-MHC ligand binding |
NKp46, Ly-94
homolog |
IgSF |
CD336 |
NK |
44kD |
activates NK
cells upon non-MHC ligand binding |
NKp44, Ly-95
homolog |
IgSF |
CD337 |
NK |
30kD |
activates NK
cells upon non-MHC ligand binding |
NKp30, Ly117 |
IgSF |
CDw338 |
stem cell
subset (side population) |
73kD |
multi-drug
resistance transporter |
ABCG2, BCRP,
Bcrp1, MXR |
GPCR 7TM |
CD339 |
stromal
cells, epithelial, AML |
135kD |
binds Notch,
hematopoiesis |
Jagged-1,
JAG1, JAGL1, hJ1 |
EGF TM |