Name |
Expression |
MW |
Function |
Other Names |
Family |
CD201 |
endoth
subset |
50kD |
activated
protein C receptor |
EPC-R |
|
CD202b |
stem cells,
endoth |
150kD |
angiopoietin-1 receptor |
Tie2, Tek |
RTK family |
CD203c |
basophils,
mast cells, glioma cells, megakaryocytes |
130-150kD |
ectoenzyme,
binding to and clearance of extracellular nucleotides |
NPP3/PDNP3,
ENpp1, PD-1b |
type II TM |
CD204 |
mac |
220kD |
endocytosis
of macromolecules |
Macrophage
scavenger-R |
|
CD205 |
DC, thymic
epith |
205kD |
DC, thymic
epith |
DEC-205 |
|
CD206 |
DC subset,
mac, mono |
180kD |
phagocytosis
and pinocytosis of mannose containing molecules |
macrophage
mannose-R |
|
CD207 |
Langerhans
cells |
40kD |
endocytic
receptor |
Langerin |
|
CD208 |
DCact,
interdigitating DC |
70-90kD |
|
DC-LAMP |
|
CD209 |
DC subset |
44kD |
ICAM-3
receptor, HIV-1 binding protein |
DC-SIGN |
|
CDw210 |
T, B, NK,
mono, mac |
90-110kD |
IL-10
receptor, signal transduction |
IL-10-R |
|
CD212 |
Tact
and NK |
100kD |
binds IL-12
w/ high affinity, associates w/ IL-12 receptor β2 |
IL-12-R β1 |
|
CD213a1 |
B, mono,
fibroblasts, endoth |
65kD |
binds IL-13
w/ low affinity, w/ CD124 |
IL-13-R α1 |
|
CD213a2 |
B, mono |
65kD |
binds IL-13
w/ high affinity |
IL-13-R α2 |
|
CDw217 |
broad |
120kD |
IL-17
receptor |
IL-17-R |
|
CDw218a |
T, NK, DCs |
70kD |
binds IL-18,
activation of NF-κB |
IL-18Rα,
IL-1Rrp |
IL-1R family |
CDw218b |
T, NK and
DCs |
70kD |
heterodimeric receptor with IL-18Rα to enhance IL-18 binding |
IL-18Rβ,
IL18RAP |
IL-1R family |
CD220 |
broad |
140, 70kD |
insulin
receptor |
Insulin-R |
|
CD221 |
broad |
140, 70kD |
binds IGF w/
high affinity, signaling, cell proliferation/ differentiation |
IGF-1 R |
|
CD222 |
broad,
90-95% intracellular |
250kD |
adhesion,
tumor growth, a receptor for TGFβ-LAP, plasminogen, proliferin,
truncated form (220kD) found in serum |
IGF-II R,
mannose-6 phosphate-R |
Type I TM |
CD223 |
Tact
and NK |
70kD |
an MHC class
II ligand |
LAG-3 |
IgSF |
CD224 |
leukocytes,
stem cells |
27, 68kD |
|
GGT |
|
CD225 |
broad |
17kD |
|
Leu-13 |
|
CD226 |
T, NK,
mono, platelets, activated HUVEC |
65kD |
activation
of cell-mediated cytotoxicity, soluble form (50kD) found in normal
serum |
DNAM-1,
PTA-1, TLiSA1 |
IgSF |
CD227 |
epith, stem
cell subset, FDC, mono, B subset, some myelomas |
300kD |
adhesion,
signaling, binds CD169, CD54, & selectins |
MUC1, EMA |
Mucin
family, type I TM |
CD228 |
stem cells,
melanomas |
80-95kD |
|
Melanotransferrin |
|
CD229 |
T, B |
95, 110kD |
adhesion |
Ly-9 |
IgSF |
CD230 |
|
35kD |
|
Prion
protein |
broad |
CD231 |
T
leukemias, neuroblastomas, brain neurons |
30-45kD |
marker for T
cell acute lymphoblastic leukemia |
TALLA-1, A15 |
TM4SF |
CD232 |
broad |
200kD |
|
VESP-R |
|
CD233 |
erythrocytes |
90kD |
anion
exchanger pump, transport of CO2,
linking red cell membrane to cytoskeleton |
Band 3,
SLC4A1 |
Anion
exchanger family |
CD234 |
erythrocytes |
35-45kD |
Duffy
antigen chemokine receptor |
Duffy, DARC |
|
CD235a |
erythrocytes |
36kD |
|
Glycophorin
A |
|
CD235ab |
erythrocytes |
20kD |
|
Glycophorin
A/B |
|
CD235b |
erythrocytes |
20kD |
|
Glycophorin
B |
|
CD236 |
erythrocytes, stem cell subset |
32, 23kD |
|
Glycophorin
C/D |
|
CD236R |
erythrocytes, stem cell subset |
32kD |
|
Glycophorin
C |
|
CD238 |
erythrocytes, stem cell subset |
93kD |
|
Kell |
|
CD239 |
erythrocytes, stem cell subset |
78-85kD |
|
B-CAM |
|
CD240CE |
erythrocytes |
30-32kD |
|
Rh30CE |
|
CD240D |
erythrocytes |
30-32kD |
|
Rh30D |
TM12SF |
CD241 |
erythrocytes |
50kD |
complex w/
CD47, LW, glycophorin B |
RhAg, Rh50 |
TM12SF |
CD242 |
erythrocytes |
42kD |
adhesion,
Landsteiner-Wiener blood group |
ICAM-4 |
IgSF |
CD243 |
stem cells,
small intestine, kidneystem cells, small intestine, kidney |
180kD |
ion pump |
MDR-1, p170,
P-gp |
|
CD244 |
T subset,
mono, basophils, NK |
70kD |
NK
activation, CD48 ligand |
2B4 |
type II TM |
CD245 |
T subset |
220-240kD |
|
p220/240 |
|
CD246 |
anaplastic
T cell leukemias, small intestine, testis, brain, not on normal
lymph |
80kD |
brain
development, implicated in ALK lymphomas |
ALK, Ki-1 |
|
CD247 |
T, NK |
16kD |
TCR complex
subunit, coupling of antigen recognition to signaling |
TCRz |
RTK family |
CD248 |
endothelial
tissue, stromal fibroblasts |
175kD |
tumor
progression and angiogenesis |
TEM1,
Endosialin |
C-Type
Lectin |
CD249 |
epith,
endoth |
160kD |
renin-angiotensin system |
Aminopeptidase A |
Peptidase M1
family |
CD252 |
Bact,
cardiac myocytes |
34kD |
T
costimulation |
OX-40Ligand,
gp34 |
TNFSF |
CD253 |
Tact,
many tissues |
|
death |
TRAIL,
Apo-2L, TL2, TNFSF10 |
TNFSF |
CD254 |
lymph node
& BM stroma Tact |
35kD |
binds OPG
and RANK, osteoclast differentiation, enhances DC to stimulate
naïve-T proliferation |
TRANCE,
RANKL, OPGL |
TNFSF |
CD256 |
mono, mac |
16kD |
binds TACI &
BCMA, B proliferation |
APRIL,
TALL-2 |
TNFSF |
CD257 |
monoact,
soluble form |
|
B cell
growth factor & costimulator of Ig production |
BLyS, BAFF,
TALL-1 |
TNFSF |
CD258 |
Tact,
immature DC |
28kD |
binds LTBR,
T proliferation, receptor for HVEM |
LIGHT,
HVEM-L |
TNFSF |
CD261 |
Tact,
peripheral blood leukocytes |
57kD |
contains
death domain, apoptosis via FADD & caspase-8 |
TRAIL-R1,
DR4 |
TNFRSF |
CD262 |
widely
expressed, peripheral blood lymphocytes |
60kD |
contains
death domain, apoptosis via FADD and caspase-8 |
TRAIL-R2,
DR5 |
TNFRSF |
CD263 |
peripheral
blood lymphocytes |
65kD |
receptor for
TRAIL but lacks death domain |
TRAIL-R3,
DcR1, LIT |
TNFRSF |
CD265 |
broad
expression |
97kD |
binds
TRANCE, osteoclastogenesis, T-DC interactions |
RANK,
TRANCE-R, ODFR |
TNFRSF |
CD266 |
heart,
placenta and kidney, HUVEC |
14kD |
TWEAK
receptor, cell-matrix interactions and endoth growth and migration |
TWEAK-R,
FGF-inducible 14 |
TNFRSF |
CD267 |
B, Tact |
|
binds BAFF &
APRIL |
TACI, TNFR
SF13B |
|
CD268 |
B |
25kD |
binds BLyS,
mature B survival |
BAFFR, TR13C |
TNFRSF |
CD269 |
mature B
(membrane and perinuclear) |
20kD |
APRIL & BAFF
receptor, B survival & proliferation |
BCMA,
TNFRSF13B |
TNFRSF |
CD271 |
neurons
(schwann cells, growing neurites), BM mesencymal cells |
45kD |
NGF, BDNF,
NT-3, & NT-4 receptor, tumor suppressor, cell survival and death |
NGFR, p75
(NTR) |
TNFRSF |
CD272 |
Tact,
B , remains on Th1 |
33kD |
HVEM
receptor, inhibitory response |
BTLA |
IgSF |
CD273 |
DC subset,
mono, mac |
25kD |
PD-1
receptor, costimulation or suppression of T proliferation |
B7DC, PD-L2,
PDCD1L2 |
IgSF |
CD274 |
leukocytes,
broad |
33kD |
PD-1
receptor, costimulation of lymphocytes |
B7-H1, PD-L1 |
IgSF |
CD275 |
B, DC, mono |
60kD |
costimulation, cytokine production |
B7-H2,
ICOSL, B7-RP1, GL50 |
B7 Family |
CD276 |
in vitro
cultured DC and mono, Tact,
mammary tissue |
40-45kD |
costimulation, T activation |
B7-H3 |
B7 Family,
ASV |
CD277 |
T, B, NK,
mono, DC, endoth, CD34+ cells, tumor cell lines |
56kD |
T activation |
BT3.1,
butyrophilin SF3 A1, BTF5 |
B7/BT
family, ASV |
CD278 |
Tact,
Th2 |
55-60kD |
binds
ICOS-L, T costimulation |
ICOS, AILIM |
CD28 family |
CD279 |
Tact
and Bact |
55kD |
B7-H1 &
B7-DC receptor, autoimmune disease and peripheral tolerance |
PD1, SLEB2 |
|
CD280 |
chondrocytes, fibroblasts, endothelial, mac |
180kD |
mannose
receptor, collagen matrix remodeling and endocytic recycling |
ENDO180,
UPARAP |
C-type
lectin SF |
CD281 |
low levels
in PBMC, mono and possibly DC |
90kD |
innate
immunity, w/ TLR2 |
TLR1 |
TLR family |
CD282 |
mono,
neutrophil, upregulated in mac |
90kD |
binds dsRNA,
response to bacterial lipoproteins, innate immunity |
TLR2 |
TLR family |
CD283 |
derived
moDC (may be intracellular) |
100kD |
binds dsRNA,
innate immunity |
TLR3 |
TLR family,
ASV |
CD284 |
PBMC (weak
in mono, immature DC & neutro) |
100kD |
binds LPS,
innate immunity |
TLR4 |
TLR family,
ASV |
CD289 |
pDC
(intracellular) |
120kD |
binds
CpG-DNA, innate immunity |
TLR9 |
TLR family |
CD292 |
bone
progenitor |
57kD |
BMP 2 & 4
receptor, bone development |
BMPR1A, ALK3 |
Type I |
CDw293 |
bone
progenitor |
57kD |
BMP
receptor, bone development |
BMPR1B, ALK6 |
Type I, ASV |
CD294 |
Th2,
eosinophils, basophils |
55-70kD |
binds
prostaglandin D2, stimulatory effects on Th2, allergic inflammation |
CRTH2. GPR44 |
GPCR-7TM |
CD295 |
broad |
132kD |
adipose
metabolism, immune dysfunction in obesity |
LeptinR,
LEPR |
Type I
cytokine-like receptor |
CD296 |
heart and
skeletal muscle, peripheral T, NK subset |
37kD |
modifies
integrins during differentiation, ADP ribosylation of target
proteins |
ART1, RT6,
ART2 |
ADP-ribosyltransferase |
CD297 |
erythroid,
monoact |
38kD |
ADP
ribosylation of target proteins |
ART4,
dombrock blood group |
ADP-ribosyltransferase |
CD298 |
broad |
52kD |
transport
sodium & potassium ions across membrane |
Na+/K+-ATPase β3 subunit |
|
CD299 |
endothelial
subset |
45kD |
binds ICAM3,
HIV-1 gp120, coreceptor w/ DC-SIGN, HIV infection |
DC-SIGN-related, LSIGN, DC-SIGN2 |
Type II,
similar to CD209, ASV |
CD300a |
NK, mono,
neutrophils, T and B subset and lymphocytic cell lines, AML |
60kD |
unknown |
CMRF35H,
IRC1, IRp60 |
IgSF, ASV |
CD300c |
mono,
neutrophils, monocytic cell lines, B & T subsets |
|
unknown |
CMRF35A, LIR |
IgSF |
CD300e |
|
|
unknown |
CMRF35L |
IgSF CMRF
family |
We thank the following organiziations for their support of the ImmunologyLink website: