Name Expression M. W. Functions Other names Family




Cortical thymocytes, Langerhans cells, Dendritic cells, B cells (CD1c), Intestinal epithelium (CD1d) 43-49 MHC class I-like molecule, associated with b2-microglobulin. May have specialised role in antigen presentation   Ig superfamily (IgSF)
CD2 T cells, thymocytes, NK cells 45-58 Adhesion molecule, binding CD58 (LFA-3). Can activate T cells T11, LFA-2 IgSF
CD2R Activated T cells 45-58 activation-dependent conformational form of CD2 T11-3 IgSF
CD3 Thymocytes, T cells g:25-28
Associated with the T cell antigen receptor. Required for cell surface expression of and signal transduction by TCR. T3 IgSF (gde) z/h related to FcR g chain
CD4 Thymocyte subsets, helper and inflammatory T cells (about two thirds of peripheral T cells), monocytes, macrophages 55 Coreceptor for MHC class II molecules. Binds lck on cytoplasmic face of membrane. Receptor for HIV-I and HIV-2 gp120. T4, L3T4 IgSF
CD5 Thymocytes, T cells, subset of B cells 67 Binds to CD72 T1, Ly1 Scavenger receptor
CD6 Thymocytes, T cells, B cell CLL 100-130 unknown. T12 Scavenger receptor
CD7 Pluripotential hematopoietic cells, thymocytes, T cells 40 unknown. Marker for T cell ALL and pluripotential stem cell leukemias   IgSF
CD8 Thymocyte subsets, cytotoxic T cells (about one third of peripheral T cells) a: 32-34
b: 32-34
Coreceptor for MHC class I molecules. Binds lck on cytoplasmic face of membrane T8, Lyt2,3 IgSF
CD9 Pre-B cells, eosinophils, basophils, platelets 22-27 possible role in platelet aggregation and activation   tetraspanning membrane protein
CD10 B and T cell precursors, bone marrow stromal cells 100 zinc metalloproteinase, marker for pre B ALL Neutral endopeptidase, Common Acute Lymphocytic Leukemia Antigen (CALLA)  
CD11a lymphocytes, granulocytes, monocytes and macrophages 180 aL subunit of integrin LFA-1 (associated with CD18) ; binds to CD54 (ICAM-1), ICAM-2 and ICAM-3 LFA-1  
CD11b myeloid and natural killer cells 170 aM subunit of integrin CR3 (associated with CD18) ; binds CD54, complement component iC3b and extracellular matrix proteins Mac-1  
CD11c myeloid cells 150 aX subunit of integrin CR4 (associated with CD18) ; binds fibrinogen CR4,
p150, 95
CDw12 monocytes, granulocytes, platelets 90-120 unknown    
CD13 myelomonocytic cells 150-170 zinc metalloproteinase amino peptidase N  
CD14 myelomonocytic cells 53-55 receptor for complex of LPS and LPS binding protein (LBP)    

& CD15S

neutrophils, eosinophils, monocytes   branched pentasaccharide, expressed on glycolipids and many cell surface glycoproteins; the sialylated form is a ligand for CD62E (ELAM) Lewsi-x (Lex)  

a & b

neutrophils, NK cells, macrophages 50-80 component of low affinity Fc receptor, FcgRIII, mediates phagocytosis and ADCC. FcgRIII IgSF
CDw17 neutrophils, monocytes, platelets   lactosyl ceramide, a cell surface glycosphingolipid    
CD18 Leukocytes 95 integrin b2 subunit, associates with CD11a,b and c.    
CD19 B cells 95 forms complex with CD21 (CR2)and CD81 (TAPA-1); coreceptor for B cells   IgSF
CD20 B cells 33-37 possible role in regulating B cell activation   tetraspanning membrane protein
CD21 mature B cells, FDC 145 receptor for complement component C3d, EBV. With CD19 and CD81 forms coreceptor for B cells CR2 complement control protein (CCP) superfamily
CD22 mature B cells a: 130
b: 140
Adhesion of B cells to monocytes, T cells BL-CAM IgSF
CD23 mature B cells, activated macrophages, eosinophils, follicular dendritic cells, platelets 45 low affinity receptor for IgE, ligand for CD19:CD21:CD81 coreceptor FceRII C-type lectin
CD24 B cells, granulocytes 35-45 unknown possible human homologue of mouse Heat Stable Antigen (HSA) or J11d.  
CD25 activated T cells, B cells, monocytes a:55
IL-2 receptor Tac a:CCP b: cytokine receptor superfamily
CD26 Activated B and T cells, macrophages 110 protease. Recently implicated in HIV entry into cells. Dipeptidyl peptidase IV  
CD27 Medullary thymocytes, T cells 50-55 unknown   NGF receptor superfamily
CD28 T cell subsets, activated B cells 44 Activation of naive T cells, receptor for costimulatory signal (signal 2) binds CD80 (B7-1) and B7-2 Tp44 IgSF
CD29 Leukocytes 130 Integrin b1 subunit, associates with CD49a in VLA-1 integrin    
CD30 Activated B and T cells 105-120 unknown Ki-1 NGF receptor superfamily
CD31 monocytes, platelets, granulocytes, B cells, endothelial cells 130-140 Possibly an adhesion molecule PECAM-1 IgSF
CDw32 Monocytes, granulocytes, B cells eosinophils 40 low affinity Fc receptor for aggregated Ig/immune complexes FcgRII IgSF
CD33 myeloid progenitor cells, monocytes 67 unknown   IgSF
CD34 hematopoietic precursors, capillary endothelium 105-120 Ligand for CD62 (L-selectin)    
CD35 Erythrocytes, B cells, monocytes, neutrophils, eosinophils, FDC 250 Complement receptor 1, binds C3B and C4b, mediates phagocytosis CR1 CCP superfamily
CD36 platelets, monocytes 88 unknown platelet GPIV  
CD37 mature B cells, mature T cells, myeloid cells 40-52 unknown   tetraspanning membrane protein
CD38 early B and T cells, activated T cells, germinal centre B cells, plasma cells 45 unknown    
CD39 activated B cells, activated NK cells, macrophages, dendritic cells 78 unknown, may mediate adhesion of B cells    
CD40 B cells, monocytes, dendritic cells 50 receptor for costimulatory signal for B cells, binds CD40 Ligand (T-BAM),   NGF receptor superfamily
CD41 platelets, megakaryocytes 125/22 dimer aIIb integrin, associates with CD61 to form GPIIb, binds fibrinogen, fibronectin, von Willebrand factor and thrombospondin    


platelets, megakaryocytes a: 23
b: 135, 23
c: 22
d: 85
binds von Willebrand factor, thrombin; essential for platelet adhesion at sites of injury a: GPIX
b: GPIba
c: GPIbb
d: GPV
CD43 leukocytes, except resting B cells 115-135 (PMN)
95-115 (T cells)
binds CD54 (ICAM-1) leukosialin, sialophorin  
CD44 leukocytes, erythrocytes 80-95 binds hyaluronic acid, mediates adhesion of leukocytes Hermes antigen, Pgp-1  
CD45 leukocytes 180-240 tyrosine phosphatase, augments signalling through antigen receptor of B and T cells, multiple isoforms result from alternative splicing (see below) Leukocyte common antigen (LCA), T200, B220  
CD45RO T cell subsets, B cell subsets, monocytes, macrophages 180 isoform of CD45 containing none of the A, B and C exons    
CD45RA B cells, T cell subsets (naive T cells) monocytes 205-220 isoforms of CD45 containing the A exon    
CD45RB T cell subsets, B cells, monocytes, macrophages, granulocytes 190-220 isoforms of CD45 containing the B exon T200  
CD45RC Restricted T200        
CD46 hematopoietic and non-hematopoietic nucleated cells 56/66 (splice variants) membrane cofactor protein, binds to C3b and C4b to permit their degradation by Factor I MCP CCP superfamily
CD47 all cells 47-52 unknown, associated with Rh blood group    
CD48 leukocytes 40-47 unknown Blast-1 IgSF
CD49a activated T cells, monocytes 210 a1 integrin, associates with CD29, binds collagen, laminin VLA-1  
CD49b B cells, monocyte, platelets 165 a2 integrin, associates with CD29, binds collagen, laminin VLA-2  
CD49c B cells 125 a3 integrin, associates with CD29, bindslaminin, fibronectin VLA-3  
CD49d B cells, thymocytes 150 a4 integrin, associates with CD29, binds fibronectin, Peyer?s Patch HEV, VCAM-1 VLA-4  
CD49e memory T cells, monocytes, platelets 135, 25 dimer a5 integrin, associates with CD29, binds fibronectin VLA-5  
CD49f memory T cells, thymocytes, monocytes 120, 25 dimer a6integrin, associates with CD29, binds laminin VLA-6  
CD50 thymocytes, T cells, B cells,monocytes, granulocytes 130 unknown  ICAM3  


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