Name |
Expression |
MW |
Function |
Other Names |
Family |
CD1a |
cortical
thymocytes, Langerhans cells, DC |
49kD |
antigen
presentation, w/ β2m |
T6 |
IgSF |
CD1b |
cortical
thymocytes, Langerhans cells, DC |
45kD |
antigen
presentation, w/ β2m |
T6 |
IgSF |
CD1c |
cortical
thymocytes, Langerhans cells, DC, B subset |
43kD |
antigen
presentation, w/ β2m |
T6 |
IgSF |
CD1d |
intestinal
epith, B subset, mono, DC |
49kD |
antigen
presentation, w/ β2m |
|
IgSF |
CD1e |
DC |
28kD |
antigen
presentation, w/ β2m |
|
IgSF |
CD2 |
thymocytes,
T, NK |
50kD |
CD58 ligand,
adhesion, T cell activation |
T11, LFA-2,
SRBC-R |
IgSF |
CD2R |
Tact |
50kD |
activation-dependent form of CD2 |
T11-3 |
IgSF |
CD3gd |
T,
thymocyte subset |
|
w/ TCR, TCR
surface expression/signal transduction |
T3 |
IgSF |
CD3e |
T,
thymocyte subset |
20kD |
w/ TCR, TCR
surface expression/signal transduction |
T3 |
IgSF |
CD4 |
thymocyte
subset, T subset, mono, mac |
55kD |
MHC class II
coreceptor, HIV receptor, T cell differentiation/activation |
T4 |
IgSF |
CD5 |
thymocytes,
T, B subset, B-CLL |
67kD |
CD72
receptor, TCR or BCR signaling, T-B interaction |
T1, Tp67 |
Scavenger R
SF |
CD6 |
thymocytes,
T, B subset |
100-130kD |
CD166
receptor, T cell differentiation/ costimulation |
T12 |
Scavenger R
SF |
CD7 |
hematopoietic progenitors, thymocytes, T, NK |
40kD |
T
costimulation |
|
IgSF |
CD8a |
thymocyte
subset, T subset, NK |
32-34kD |
MHC class I
coreceptor, receptor for some mutated HIV-1, T cell
differentiation/activation |
T8, Leu-2 |
IgSF |
CD8b |
thymocyte
subset, T subset |
30-32kD |
|
|
IgSF |
CD9 |
pre-B,
eosinophils, basophils, platelets, Tact |
22-27kD |
cellular
adhesion and migration |
p24, MRP-1 |
TM4SF |
CD10 |
B
precursors, T precursors, neutrophils |
100kD |
zinc-binding
metalloproteinase, B cell development |
CALLA, NEP,
gp100 |
type II TM |
CD11a |
lymph,
gran, mono, mac |
180kD |
CD11a/CD18
receptor for ICAM-1, -2,-3, intercellular adhesion, T costimulation |
LFA-1,
integrin αL |
Integrin
family |
CD11b |
myeloid
cells, NK |
170kD |
binds CD54,
ECM, iC3b |
Mac-1,
integrin αM |
Integrin
family |
CD11c |
DC, myeloid
cells, NK, B, T subset |
150kD |
binds CD54,
fibrinogen and iC3b |
p150, 95,
CR4, integrin αX |
Integrin
family |
CDw12 |
mono, gran,
platelets |
90-120kD |
|
|
|
CD13 |
myeloid
cells |
150-170kD |
zinc-binding
metalloproteinase, antigen processing, receptor for corona virus
strains |
Aminopeptidase N, APN |
type II TM |
CD14 |
mono, mac,
Langerhans cells, granlow |
53-55kD |
receptor for
LPS/LBP, LPS recognition |
LPS-R |
GPI-linked |
CD15 |
neutrophils, eosinophils, mono |
|
adhesion |
Lewis-x, Lex |
CHO |
CD15s |
neutrophils, eosinophils, mono, memory helper T, and B, NK, HEV |
|
CD62L and
CD62P ligand, adhesion |
Sialyl Lewis
X |
CHO |
CD15u |
myeloid
subset |
|
adhesion |
Sulfated
Lewis X |
CHO |
CD16a |
neutrophils, mac, NK |
50-65kD |
component of
low affinity Fc receptor, phagocytosis and ADCC |
FcγRIIIA |
IgSF |
CD16b |
neutrophils |
48kD |
component of
low affinity Fc receptor, phagocytosis and ADCC |
FcγRIIIB |
IgSF |
CDw17 |
neutrophils, mono, platelets |
|
lactosyl
ceramide |
|
|
CD18 |
broad, all
leukocytes |
95kD |
w/ CD11a, b
& c, adhesion |
Integrin β2 |
Integrin
family |
CD19 |
B, FDC |
95kD |
complex w/
CD21and CD81, BCR coreceptor, B cell activation/ differentiation |
B4 |
IgSF |
CD20 |
B, T subset |
33-37kD |
B cell
activation |
B1, Bp35 |
TM4SF |
CD21 |
B, FDC, T
subset |
145,110kD |
complement
C3d and EBV receptor, complex w/ CD19 and CD81, BCR coreceptor |
C3DR, CR2,
EBV-R |
CCRSF |
CD22 |
B |
150kD |
adhesion,
B-mono, B-T interactions |
BL-CAM,
Siglec-2 |
IgSF,
sialoadhesins |
CD23 |
B,
activated mac, eosinophils, FDC, platelets |
45kD |
CD19-CD21-CD81 receptor, IgE low affinity receptor, signal
transduction |
FcεRII |
C-type
lectin |
CD24 |
thymocytes,
erythrocytes, peripheral lymph, myeloid |
35-45kD |
binds
P-selectin |
BA-1 |
GPI-linked |
CD25 |
Tact,
Bact,
lymph progenitors |
55kD |
IL-2Rα, w/
IL-2Rβ and γ to form high affinity complex |
Tac, p55 |
type I TM |
CD26 |
thymocyte
subset, Tact,
soluble form |
110kD |
dipeptidyl
peptidase, T costimulation, HIV entry |
DPP IV |
type II TM |
CD27 |
medullary
thymocytes, T, B subset, NK subset |
50-55kD |
CD70
receptor, T costimulation |
T14 |
TNFRSF |
CD28 |
most T,
thymocytes, plasma cells |
44kD |
CD80, CD86
receptor, T costimulation |
Tp44, T44 |
IgSF |
CD29 |
lymph,
mono, granlow,
platelets, mast cells, fibroblasts, endoth |
130kD |
w/ CD49a
(VLA-1) receptor for VCAM-1, MAdCAM-1 and ECM |
Integrin β1 |
Integrin
family |
CD30 |
Bact,
T and NK , Reed-Sternberg cells, anaplastic large cell lymphoma |
105-120kD |
CD153
receptor, lymph proliferation/ apoptosis |
Ki-1 |
TNFRSF |
CD31 |
mono,
platelets, gran, endoth, lymph subset |
130-140kD |
CD38
receptor, adhesion |
PECAM-1 |
IgSF |
CD32 |
mono, gran,
B, platelets |
40kD |
low affinity
Fc receptor for aggregated Ig and immune complexes |
FcγRII |
IgSF |
CD33 |
myeloid
progenitors, mono, gran, DC, mast cells, Tact |
67kD |
adhesion |
p67,
Siglec-3 |
IgSF,
sialoadhesins |
|
|
|
|
|
|
CD34 |
hematopoietic precursors, capillary endoth, embryonic fibroblasts |
105-120kD |
stem cell
marker, adhesion, CD62L receptor |
|
Sialomucin,
type I TM |
CD35 |
erythrocytes, B, mono, neutrophils, eosinophils, FDC, T subset |
250kD |
complement
receptor 1, binds C3b and C4b, adhesion, phagocytosis |
CR1 |
CCRSF |
CD36 |
platelets,
mono, mac, endoth, early erythrocytes |
88kD |
ECM
receptor, adhesion, phagocytosis |
GPIV |
|
CD37 |
B, Tlow,
granlow |
40-52kD |
signal
transduction |
|
TM4SF |
CD38 |
variable
levels on majority of hematopoietic cells, high expression on plasma
cells, B and Tact |
45kD |
ecto-ADP-ribosyl cyclase, cell activation |
T10 |
|
CD39 |
B cell
adhesion, protects activated cells from lysis, ecto-apyrase |
78kD |
|
|
NK, mac,
Langerhans cells, DC, Bact |
CD40 |
B, mono,
mac, FDC, endoth, T subset |
48kD |
CD154
receptor, B differentiation/ costimulation, isotype-switching,
rescues B cells from apoptosis |
|
TNFRSF |
CD41 |
platelets,
megakaryocytes |
125/22kD |
w/ CD61
forms GPIIb, binds fibrinogen, fibronectin, vWF, thrombospondin,
platelet activation and aggregation |
gpIIb |
Integrin
family |
CD42a |
platelets,
megakaryocytes |
22kD |
complex w/
CD42b, c and d, receptor for vWF and thrombin, platelet adhesion to
subendothelial matrices |
GPIX |
LRRF |
CD42b |
platelets,
megakaryocytes |
145kD |
complex w/
CD42a, c and d, binds to vWF and thrombin, platelet adhesion/
activation |
GPIba |
LRRF |
CD42c |
platelets,
megakaryocytes |
24kD |
complex w/
CD42a, b, d |
GPIbb |
LRRF |
CD42d |
platelets,
megakaryocytes |
82kD |
complex w/
CD42a-c |
GPV |
LRRF |
CD43 |
leukocytes,
except resting B, plateletslow |
115-135kD |
inhibition
of T cell interaction, CD54R, adhesion |
Leukosialin,
sialophorin |
Sialomucin,
type I TM |
CD44 |
hematopoietic and non-hematopoietic cells, except platelets,
hepatocytes, testis |
80-95kD |
binds
hyaluronic acid, adhesion |
H-CAM, Pgp-1 |
hyaladherin
family |
CD44R |
CD44
variants heterogeneous expression, constitutively on epith, mono,
upregulated on activated leukocytes |
|
adhesion,
metastasis |
CD44v |
|
CD45 |
hematopoietic cells, multiple isoforms from alternative splicing |
180-240kD |
tyrosine
phosphatase, enhanced TCR & BCR signals |
LCA, T200,
B220 |
|
CD45RA |
B, T
subset(naive), mono |
205-220kD |
exon A
isoforms of CD45 |
|
|
CD45RB |
T subset,
B, mono, mac, gran |
190-220kD |
exon B
isoforms of CD45 |
|
|
CD45RO |
Tact,
memory T, B subset, mono, mac, gran |
180kD |
isoform of
CD45 lacking A, B, C exons |
|
|
CD46 |
nucleated
cells |
56/66kD |
membrane
cofactor protein, binds C3b & C4b allowing degradation by Factor I,
measles virus receptor |
MCP |
CCRSF |
CD47 |
hematopoietic cells, epith, endoth, fibroblasts, other tissues |
47-52kD |
leukocyte
adhesion, migration, activation |
IAP |
IgSF |
CD47R |
New
designation for CDw149, similar distribution as CD47 but dimmer |
|
|
|
|
CD48 |
broad, all
leukocytes |
45kD |
cell
adhesion |
Blast-1 |
IgSF |
CD49a |
Tact,
mono |
210kD |
integrin α1,
adhesion, CD49a/CD29 binds collagen and laminin |
VLA-1 |
Integrin
family |
CD49b |
B, mono,
platelets, Tact,
megakaryocytes |
165kD |
integrin α2,
adhesion, CD49b/CD29 binds collagen and laminin |
VLA-2 |
Integrin
family |
CD49c |
B and Tlow,
most adhesive cell lines |
125kD |
integrin α3,
adhesion, CD49c/CD29 binds laminin, fibronectin and collagen |
VLA-3 |
Integrin
family |
CD49d |
T, B, NK,
thymocytes, mono, eosinophils, mast, DC |
150kD |
integrin α4,
adhesion, CD49d/CD29 binds fibronectin, VCAM-1 & MAdCAM-1 |
VLA-4 |
Integrin
family |
CD49e |
thymocytes,
T, mono, platelets, early and Bact |
135, 25kD |
integrin α5,
adhesion, CD49e/CD29 binds fibronectin |
VLA-5 |
Integrin
family |
CD49f |
memory T,
thymocytes, mono, platelets, megakaryocytes, epith |
125kD |
integrin α6,
adhesion, CD49f/CD29 binds laminin |
VLA-6 |
Integrin
family |
CD50 |
hematopoietic, endoth, epidermal Langerhans cells |
110-120kD |
adhesion,
costimulation |
ICAM-3 |
IgSF |
CD51 |
plateletslow,
endoth, osteoblasts, melanomas |
125, 24kD |
integrin αv,
adhesion, CD51/CD61 binds vitronectin, vWF, fibrinogen and
thrombospondin |
Vitronectin
receptor |
Integrin
family |
CD52 |
thymocytes,
T, B (not plasma cells), mono, mac |
21-28kD |
|
CAMPATH-1 |
|
CD53 |
leukocytes,
DC, osteoblasts, osteoclasts |
35-42kD |
signal
transduction |
|
TM4SF |
CD54 |
endoth,
mono, lymph (high upon activation) |
90-110kD |
receptor for
CD11a/CD18 (LFA-1), CD11b/CD18 (Mac-1) and rhinovirus |
ICAM-1 |
IgSF |
CD55 |
hematopoietic, endoth |
60-70kD |
binds C3b,
complement regulation |
DAF |
GPI-linked |
CD56 |
NK, T
subset, neurons, some large granular lymphocyte leukemias, myeloid
leukemias |
175-185kD |
adhesion |
NCAM |
IgSF |
CD57 |
NK subset,
T subset |
110kD |
|
HNK-1, Leu-7 |
|
CD58 |
hematopoietic, non-hematopoietic cells |
55-70kD |
CD2
receptor, adhesion |
LFA-3 |
IgSF |
CD59 |
hematopoietic, non-hematopoietic cells |
19kD |
binds
complement C8 and C9, blocks assembly of membrane attack complex |
Protectin,
MAC- inhibitor |
GPI-linked |
CD60a |
T subset,
platelets, thymic epith, astrocytes |
|
costimulation |
GD3 |
CHO |
CD60b |
T subset, Bact |
|
|
9-O-sialyl
GD3 |
CHO |
CD60c |
T subset |
|
|
7-O-sialyl
GD3 |
CHO |
CD61 |
platelets,
megakaryocytes, mac, endoth |
105kD |
integrin β3,
adhesion, CD41/CD61 or CD51/CD61 mediate adhesion to ECM |
GPIIIa |
Integrin
family |
CD62E |
endoth |
97,107-115kD |
binds CD15s,
cell rolling, metastasis |
E-selectin,
ELAM-1 |
Selectin
family |
CD62L |
B, naïve
and memory T, mono, gran, NK, thymocytes |
74, 95kD |
CD34,
GlyCAM, and MAdCAM-1 receptor, leukocyte homing, tethering, rolling |
L-selectin,
LECAM-1 |
Selectin
family |
CD62P |
activated
platelets, endoth |
140kD |
CD162, CD15s
receptor, adhesion, neutrophil rolling, platelet-neutrophil and
platelet-mono interactions |
P-selectin,
PADGEM |
Selectin
family |
CD63 |
activated
platelets, mono, mac |
53kD |
lysosomal
membrane protein, moves to cell surface after activation |
LIMP, LAMP-3 |
TM4SF |
CD64 |
mono, mac,
DC, Interferon or G-CSF activated gran |
72kD |
high
affinity receptor for IgG, phagocytosis and ADCC |
FcγRI |
IgSF |
CD65 |
gran, mono
subset, myeloid leukemias |
|
|
|
|
CD65s |
gran, mono,
myeloid leukemias |
|
phagocytosis |
VIM2 |
|
CD66a |
neutrophils, epith |
160-180kD |
cell
adhesion |
BGP-1,
NCA-160 |
IgSF, CEA
family |
CD66b |
gran |
95-100kD |
cell
adhesion, neutrophil activation |
CD67, CGM6 |
IgSF, CEA
family |
CD66c |
neutrophils, colon carcinoma |
90kD |
cell
adhesion |
NCA |
IgSF, CEA
family |
CD66d |
neutrophils |
35kD |
|
CGM1 |
IgSF, CEA
family |
CD66e |
colon
epith, colon cancer |
180-200kD |
cell
adhesion |
CEA |
IgSF, CEA
family |
CD66f |
pregnancy
specific glycoprotein, placental syncytiotrophoblasts, fetal liver |
54-72kD |
immune
regulation, protects fetus from maternal immune system |
PSG, Sp-1 |
IgSF, CEA
family |
CD68 |
intracellularly in mono, mac, neutrophils, basophils, large lymph,
mast cells, DC, myeloid progenitors, liver |
110kD |
|
Macrosialin,
gp110 |
Sialomucin |
CD69 |
Tact,
B, NK and gran, thymocytes, platelets, Langerhans cells |
28, 32kD |
signal
transduction |
AIM |
C-type
lectin |
CD70 |
Bact
and Tact |
50, 70, 90,
160kD |
CD27 ligand,
T and B cell costimulation |
Ki-24 |
TNFSF |
CD71 |
proliferating cells, reticulocytes, erythroid precursors |
95kD |
transferrin
receptor, iron uptake |
T9 |
|
CD72 |
B, FDC |
42kD |
CD5, CD100
receptor, B proliferation |
Lyb-2 |
C-type
lectin |
CD73 |
B subset, T
subset, FDC, epith |
69kD |
ecto-5’-nucleotidase, nucleoside uptake, T costimulation, lymph
adhesion |
|
GPI-linked |
CD74 |
B, mac,
mono, Langerhans cells, DC, Tact |
33, 35, 41,
43kD |
MHC class II
traffic and function |
Ii,
invariant chain |
|
CD75 |
B subset,
epith |
|
lactosamines |
|
CHO
Sialoglycan family |
CD75s |
B subset, T
subset |
|
α-2,6-sialylated lactosamines (previously CDw75 and CDw76) |
|
CHO
Sialoglycan family |
CD77 |
germinal
center B, Burkitt’s lymphomashigh,
follicular lymphomaslow |
|
apoptosis |
Gb3, Pk
blood group |
|
CD79a |
B |
33, 45kD |
component of
BCR, BCR surface expression and signal transduction |
Iga |
IgSF |
CD79b |
B |
37kD |
component of
BCR, BCR surface expression and signal transduction |
Igb |
IgSF |
CD80 |
Bact
and Tact,
mac, DC |
60kD |
binds to
CD28, CD152, T costimulation |
B7, B7-1,
BB1 |
IgSF |
CD81 |
T, B, NK,
thymocytes, DC, endoth, fibroblast, neuroblastomas, melanomas |
26kD |
complex w/
CD19 & CD21, signaling, T costimulation |
TAPA-1 |
TM4SF |
CD82 |
leukocytes |
50-53kD |
signal
transduction |
R2 |
TM4SF |
CD83 |
Bact
and Tact,
DC, Langerhans cells |
43kD |
|
HB15 |
IgSF |
CDw84 |
mono,
platelets, B, T subset, mac subset |
73kD |
|
|
|
CD85 |
DC, mono,
B, NK, T subset |
110kD |
inhibition
of NK, T cell cytolytic function |
|
IgSF,
ILT/LIR family |
CD86 |
mono, DC, Bact
and Tact |
80kD |
binds to
CD28, CD152, T costimulation |
B70, B7-2 |
IgSF |
CD87 |
gran, mono,
NK, Tact,
endoth, fibroblasts |
39-66kD |
urokinase
plasminogen activator receptor, inflammatory cell invasion,
metastasis |
UPA-R |
GPI-linked |
CD88 |
gran, mono,
DC |
40kD |
C5a
receptor, granulocyte activation |
C5aR |
TM7SF |
CD89 |
mono, mac,
gran, neutrophils, B subset, T subset |
55-75kD |
IgA
receptor, phagocytosis, degranulation, respiratory burst |
FcαR |
IgSF |
CD90 |
CD34+
hematopoietic subset, neurons |
25-35kD |
hematopoietic stem cell and neuron differentiation |
Thy-1 |
IgSF,
GPI-linked |
CD91 |
mono, mac,
neurons, fibroblasts |
600kD |
receptor for
α-2-macroglobulin |
|
LDLR family |
CDw92 |
neutrophils, mono, platelets, endoth, fibroblasts |
70kD |
|
|
|
CD93 |
neutrophils, mono, endoth |
120kD |
|
|
|
CD94 |
NK, T
subset |
43kD |
complex w/
NKG2, inhibits NK function |
KP43 |
C-type
lectin |
CD95 |
lymph (high
upon activation), mono, neutrophils |
45kD |
FasL (CD178)
receptor, apoptosis |
Apo-1, Fas |
TNFRSF |
CD96 |
NK, Tact |
160kD |
adhesion of
activated T and NK |
TACTILE |
IgSF |
CD97 |
Bact
and Tact,
mono, gran |
74, 80, 90kD |
|
|
TM7SF |
CD98 |
T, B, NK,
gran, all human cell lines |
80, 40kD |
cellular
activation |
4F2 |
|
CD99 |
leukocytes |
32kD |
T cell
activation, adhesion |
MIC2, E2 |
|
CD99R |
T, NK,
myeloid cells |
32kD |
isoform of
CD99 |
E2 |
|
CD100 |
hematopoietic cells except immature bone marrow cells, RBC and
platelets |
150kD |
cell
adhesion, cellular activation |
|
|
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